short strands of DNA as siklusisasi (above), but the existence of the molecule interkalator (green) form a long chain polymerik
U.S. investigators have revealed new clues about how the earliest life forms have been arranged in the primordial soup. The secret is the possibility of "molecular midwife" - compounds that play a crucial role in the combination of small nucleotide fragments in a first polymeric material genetically.
"There are so many unanswered questions about how the genetic polymer formed in the prebiotic Earth's age - ie without the presence of enzyme proteins that exist today," said Nicholas Hud, who led the research at the Institute of Technology Georgia. "We are investigating how a small nucleotide fragment could join a long polymer - DNA or RNA strands to form the beginning."
One problem in investigating how DNA begins to form a small chain of nucleotides - from three to four bases long - flexible enough to bind. Also they like and tend to bond mengriting intramolekular and circular, forming a small ring of the chain length.
Today, Hudson's team has found that the presence of certain compounds can menstabilakan development of DNA strands. Compounds known as interkalator - large, flat molecules that can slide between the bases in DNA as a plank of wood - by holding the structure in place by non-covalent interactions. These compounds are called by the name of molecular midwife for this team, because this polymer is sometimes no longer needed.
Two examples of these are midwives Ethidium Coralynes - multicincin general organic compounds, but unlike these two compounds is the first time a midwife. "Our work suggests that the possible existence of flat molecules midwives who participated in the beginning of life on Earth," says Hood. "But this is still not identified and may be there too."
An interesting perspective is the first molecular midwife is responsible for selecting a combination of base paangan adenine-thymine (AT) and cytosine-guanine (CG) DNA does. As can stabilize ethidium diteemukan Watson-Crick pairs traditional aza3 azacyanine found to stabilize an alternative system in which binding of adenine adenine (AA).
"Midwives different molecular can be selective in the installation of the system is fundamentally different," says Hood. "Our hypothesis is that the original molecule midwives help choosing a partner base that is used in the DNA."
"This study shows a very good thing at all that a combination of nucleic acid molecules that are structurally independent seem to produce systems that can replicate - and later in life - from the nucleic acid itself," said Clemens Richert, expert DNA at the University of Stuttgart, Germany.
U.S. investigators have revealed new clues about how the earliest life forms have been arranged in the primordial soup. The secret is the possibility of "molecular midwife" - compounds that play a crucial role in the combination of small nucleotide fragments in a first polymeric material genetically.
"There are so many unanswered questions about how the genetic polymer formed in the prebiotic Earth's age - ie without the presence of enzyme proteins that exist today," said Nicholas Hud, who led the research at the Institute of Technology Georgia. "We are investigating how a small nucleotide fragment could join a long polymer - DNA or RNA strands to form the beginning."
One problem in investigating how DNA begins to form a small chain of nucleotides - from three to four bases long - flexible enough to bind. Also they like and tend to bond mengriting intramolekular and circular, forming a small ring of the chain length.
Today, Hudson's team has found that the presence of certain compounds can menstabilakan development of DNA strands. Compounds known as interkalator - large, flat molecules that can slide between the bases in DNA as a plank of wood - by holding the structure in place by non-covalent interactions. These compounds are called by the name of molecular midwife for this team, because this polymer is sometimes no longer needed.
Two examples of these are midwives Ethidium Coralynes - multicincin general organic compounds, but unlike these two compounds is the first time a midwife. "Our work suggests that the possible existence of flat molecules midwives who participated in the beginning of life on Earth," says Hood. "But this is still not identified and may be there too."
An interesting perspective is the first molecular midwife is responsible for selecting a combination of base paangan adenine-thymine (AT) and cytosine-guanine (CG) DNA does. As can stabilize ethidium diteemukan Watson-Crick pairs traditional aza3 azacyanine found to stabilize an alternative system in which binding of adenine adenine (AA).
"Midwives different molecular can be selective in the installation of the system is fundamentally different," says Hood. "Our hypothesis is that the original molecule midwives help choosing a partner base that is used in the DNA."
"This study shows a very good thing at all that a combination of nucleic acid molecules that are structurally independent seem to produce systems that can replicate - and later in life - from the nucleic acid itself," said Clemens Richert, expert DNA at the University of Stuttgart, Germany.
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